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It’s important to note that it takes more than two half-lives for the body to completely clear tramadol. The half-life of tramadol is approximately 6 hours.
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This also helps determine the amount of time it takes that tramadol use can be detected after last use and can affect how long tramadol will stay in the body. In this context, this term in relation to tramadol is how long it takes the body to eliminate half the concentration of tramadol after your last dose. What is the half-life of tramadol?īiological half-life refers to how long it takes for the concentration of something to decrease by half. The body quickly absorbs tramadol, and eventually excretes it primarily through urine as an unchanged drug (roughly 30% of the dose) and as metabolites (60%), according to the World Health Organization (WHO). Do not crush or chew sustained-release medications, unless directed by a physician.
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However, the sustained-release capsules of tramadol release over a greater period of time. Tramadol has an oral bioavailability of roughly 70% after the first dose, which increases up to 90% or even 100% following subsequent doses this bioavailability is the same for both immediate-release and sustained-release capsules.